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The SANAD Study of Effectiveness of Valproate,Lamotrigine,or Topiramate for Generalised and Unclassifiable Epilepsy:An Unblinded Randomised Controlled Trial
Lancet 369:1016-1026, Marson,A.G.,et al, 2007
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Article Abstract
Valproate is better tolerated than topiramate and more efficacious than lamotrigine, and should remain the drug of first choice for many patients with generalised and unclassified epilepsies. However, because of known potential adverse effects of valproate during pregnancy, the benefits for seizure control in women of childbearing years should be considered.
 
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